22254-24-6 8-Isopropylatropinium bromide

Ko te Ipratropium bromide e mohiotia ana ko Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, me te ipratropium bromide.He paura tioata ma me te reka kawa.Ira whakarewa 232 ℃-233 ℃.Wairewa i roto i te wai, paku wairewa ki te waihā, karekau ki etahi atu whakarewa waro.Ingoa matū: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.He rongoa anticholinergic, he kaha whakangā ki runga i nga uaua maeneene o te bronchial me te paanga antiasthmatic ki runga i te mate o te puku arai mau tonu.Ka kitea tona paanga, te tere tere me te roa o te waa.Ko te Ipratropium bromide hoki e whakahaere ana i te hunanga o nga repe hūpē me te whakapai ake i te nekehanga ciliary, na reira ka whakaiti i te aukati i te sputum hei whakapai ake i te hau.I tenei wa, ko te whakahekenga o te sputum ka whakaitihia te bronchospasm i puta mai i te riri o te bronchial.Mo te aukati me te maimoatanga o te mate huango bronchial me te bronchitis tawhito huango, ina koa mo nga turoro e kore e kaha ki te whakamahi i te wiri uaua β-agonist, tachycardia.Ka taea te whakamahi i tenei hua me nga beta-agonists hei whakarei ake i te kaha o tetahi ki tetahi, penei i te whakakotahitanga me te finoterol hei hanga i te aerosol (BERODU -- AL) mo te mate huango, te bronchitis roa me te emphysema.Ka whakatauritea ki nga kaiwhakatairanga β-adrenergic receptor (hei tauira, isopropyl epinephrine), he iti ake nga paanga o tenei hua ki te taha cardiovascular, ka whakatauritea ki nga kaiwhakatairanga β2-receptor (hei tauira, Suquanling), he kaha ake te mana whakahaere o tenei hua ki runga i te rōrahi phlegm.
Rehu inhalation.40 ~ 80μg kotahi, 2 ~ 4 wa ia ra.I te wa e whakamahi ana, me tango tuatahi te taupoki anga anga, tuu te uhi anga whiti kanohi ki runga i te puha, hurihia te pounamu ki raro, kia mau te anga uhi ki roto i te waha, whai ki te korokoro, momi i te hau i te wa ano, pehia te puha. i runga i te takirere, kapohia te wai, ka mau i to manawa mo te wa poto.Whakahokia te mahanga i runga ake ina tika.Aerosol: 0.025% otinga.Papa: 10mg/papa.
Ka taea te rongoa i te paihana anticholinergic nui ki te aukati cholinesterase.
He rite nga tauhohenga kino o te ipratropium bromide ki te atropine, ka taea te pupuhi, te mahunga, te mangere, te mataku, te nausea, te ruaki, te mamae o te kopu, te wiri, te tirohanga matakite, te waha maroke, te maremare, te dysuria, te whakararu o nga tohu manawa me te pupuhi.
Ko te Ipratropium bromide he antagonist muscarinic, bronchodilator, me te tote isopropyl o AtropineN.
Ko te Ipratropiumbromide me te Formoterol tetahi waahanga hei tiaki i nga ngongo mai i te mumura mau tonu me te whakanui i nga ngongo, te whakaiti i nga neutrophils ma te aukati i te mahi ma te MMP-9.Ko te Ipratropiumbromide(1nM) i tino whakanui ake i te konupūmā bromide, i whakaiti i te marara whakamua me te whakanui ake i te here a annexin-V.I muri i te maimoatanga o te Ipratropiumbromide, ka piki ake te hemolysis engari he tino nui.Ko te Ipratropiumbromide ka mate whakamomori i te toto toto whero, i te eryptosis ranei, na te whakaongaonga o te konupūmā.
Ipratropium maroke paura inhalation (DPI) he bronchodilator whai hua i roto i te okiokinga hoiho i te horopeta o 2400 mg / hoiho, me te iti o te painga ki runga i te rererangi rererangi o runga i te wa e whakaora ana.I roto i nga kiore kua tukinotia e te cadmium, i tino whakahekehia e te Ipratropium te rerenga o nga pūtau mumura o te parenchymal me te kite i nga reinga o te huhu e piri ana.Ko te Ipratropium he tiaki i nga ngongo mai i te mumura ma te whakaiti i te whakaurunga neutrophil.I roto i nga uaua maeneene o te poaka poaka, ko te Ipratropium he kaitukino e aukati ana i te kaikawe aukati muscarinic o mua o te nerve parasympathetic pūkahukahu.Kua whakaatuhia hoki te Ipratropium he antagonist kaha i muri i te here ki nga kaiwhakawhiwhi aukati muscarinic.Ka whakaitihia e te Ipratropium nga huringa teitei o te pehanga o te uma me te whakanui ake i te kaha o te mahi (Cdyn) i roto i te manawa taima (te pikinga Pplmax) me te parenga pulmonary (RL) i roto i nga hoiho.