Haina 130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester) -methyl ester Kaihanga me te wheketere |Jiayinglai

130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester

Whakaahuatanga Poto:

Te ahua	Maama ki te Kiriata-White ranei te paura tioata.
MF	C12H21NO6
MW	275.3
Maamaa	98+

Tukuna he imeera ki a matou

Taipitopito Hua

Te tikanga kawe me te tikanga tuku e taunaki ana:
ma te hau, ma te moana, ma te tere ranei

Tikanga rokiroki:
Puritia ki te wahi pouri, Hiri ki te maroke, Te Pawera Rua

Te Rahi Ota Mokito:
Te whiriwhiringa

Tiwhikete:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e waatea ana

Nga kupu taurite

dimethyl(tert-butoxycarbonyl)-D-glutamate;
(R)-2-tert-Butoxycarbonylamino-pentanedioic acid dimethyl ester;
(Tert-Butoxy)Carbonyl D-Glu(OMe)-OMe (Syrup);
Boc-D-Glu(OMe)-OMe (Syrup);
dimethyl (2R) -2- [(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate;
Alogliptin poke 43;
1,5-dimethyl (2R)-2- {[(tert-butoxy)carbonyl]amino}pentanedioate

Te takai o roto

I te nuinga o te wa ka whakamahia ki te kohi paura.A ka taea e ratou te aukati i te ra me te wai kia kino.

tarapi waho

Ka taea e te kaata pakeke te tiaki i o hua mai i te pakaru me te makuku.

Nga tono

Ko nga Fluoroquinolones he whanui antibacterial spectrum, he kaha antibacterial mahi, he iti nga tauhohenga kino, he pai te urunga o te kiko, he nui te koiora o te waha, he wa roa te whakahaere me te watea te whakahaere.Ka whakamahia i te nuinga o te waa ki te rongoa i nga mate hopuhopu penei i te mate rewharewha me te mate urinary tract.Ko te hanganga o nga raau taero antibacterial fluoroquinolone e whakaatuhia ana e te aroaro o te fluorine i te ono o nga tuunga o te quinolone matua karihi.
Heoi, i roto i nga tau 10 tata nei, na te pehanga whiriwhiri i puta mai i te whanuitanga o te whakamahinga o tenei momo raau taero, ka piki ake nga riipene aukati tarukino, ina koa i nga tau tata nei, ko te quinolone-resistant Streptococcus pneumoniae he parenga whakawhiti, he aukati ki te penicillin, nga rongoā paturopi macrolide me nga paturopi quinolone.I te wa ano, i kitea ka taea e etahi fluoroquinolones te whakaroa i te wa QTc o te electrocardiogram, te hepatotoxicity me te phototoxicity, i iti ai to raatau tono.
Hei hinga i nga ngoikoretanga o runga ake nei o nga fluoroquinolones, he mea akiaki ki te whakawhanake i nga puhui hanganga hou me te mahi antibacterial pai, te whanui antibacterial whanui me te iti rawa o nga tauhohenga kino ki nga huakita aukati maha-taakaro.He raupapa o nga raau taero hou-kore-fluoroquinolone (NFQ) hou kei roto ko te 8-methoxyl he rereke mai i nga paturopi fluoroquinolone i te mea kaore he fluorine i runga i te turanga 6 o te nucleus matua quinolone, engari he kaha tonu te mahi antibacterial in vitro.Ko te nemonoxacin he aukati topoisomerase huakita NFQ hou.
Ka whakatauritea ki nga fluoroquinolones i tenei wa kei te maakete, ko te Nenofloxacin te tohu mo te roopu hou o nga raau taero.nemonocacin (TG-873870), he tarukino quinolone hou i whakawhanakehia e Procter & Gamble (P&G), i whakaatu i te mahi antibacterial nui ki te maha o nga momo tukumate e pa ana ki te haumanu, tae atu ki te Staphylococcus aureus me te Streptococcus pneumoniae-atete maha.Ko nga hua o te whakamatautau i nga kiore kua pangia i whakaatu ko te kaha antibacterial o tenei hua he kaha ake i te nuinga o nga quinolones o naianei.I tua atu, he pai nga ahuatanga o te pharmacokinetic o te hua me te pai te whakamana.

hua e pa ana

Fmoc-Gly-glu(otbu)-aue	Boc-D-Glu(OBzl)-Oet
HL-Glu-OH	Boc-D-Glu(Obzl)-OH
HD-Glu-OH	Boc-D-Glu(Ome)-OH
DL-Glu-OH	Boc-D-Glu(Ome)-OH.DCHA
DL-Glu-OH.H2O	Boc-Glu(OBzl)-Obzl
L-Glu(Obzl)-NCA	Boc-L-Glu-OBzl
D-Glu(Obzl)-NCA	Boc-D-Glu-Obzl
DL-Glu(Obzl)-NCA	Boc-D-Glu-Otbu-OH
L-Glu-Obzl	Boc-D-Glu(OMe)-OMe
Tos-Glu-Obzl	Boc-D-Glu(Obzl)-Obzl
L-Glu(Ome)-Obzl.TOS	Boc-L-Glu(Ome)-Ome
AC-Glu(OtBu)	Boc-L-Glu(OMe)-OH
DL-Glu(Ome)	Boc-L-Glu(OBzl)-OH
HD-Glu(OMe)-OH	Boc-Glu-Otbu
HL-Glu(OMe)-OH	Boc-L-Glu(Obzl)-Ome
L-Glu(Obzl)	Boc-L-Glu(Oet)
HL-Glu(OtBu)-OH	Fmoc-L-Glu-OH
HL-Glu(OEt)-OH	Fmoc-D-Glu-OH
L-Glu(Otbu)-Otbu-OH	Fmoc-D-Glu(Ome)-OH
HD-Glu(OBzl)-OH	Fmoc-L-Glu(OcHx)-OH
D-Glu-OBzl	Fmoc-L-Glu(OMe)-OH
HL-Glu(Ome)-Otbu.Hcl	Fmoc-L-Glu(OtBu)-OH
D-Glu(Obzl)-Otbu.HCL	Fmoc-D-Glu(OBzl)-OH
D-Glu(OtBu)-OtBu•HCl	Fmoc-D-Glu(Otbu)-OH
L-Glu(OcHx).hcl	Fmoc-L-Glu-OtBu
HL-Glu(OBzl)-OBzl.HCl	Fmoc-L-Glu(OBzl)-OH
HL-Glu-OBzl.HCl	Fmoc-L-Glu(Cbz-ae)
D-Glu(OBzl)-OBzl.HCl	Fmoc-N-Me-L-Glu(Otbu)-OH
DL-Glu(Ome)-Ome.Hcl	Fmoc-glu-obzl
HL-Glu(OtBu)-OtBu•HCl	Cbz-L-Glu-OH
HL-Glu(OMe)-OMe.HCl	Cbz-D-Glu-OH
L-Glu(Obzl)-OME.HCL	ZL-Glu-OBzl
HL-Glu(OEt)-OEt·HCl	ZD-Glu-OBzl
L-Glu(Obzl)-Otbu.HCl	Cbz-L-Glu-Otbu
HD-Glu(OMe)-OMe·HCl	Cbz-D-Glu(ome)
N-Pht-Glu	Cbz-L-Glu(OBzl)-OH
Boc-L-Glu-OH	Cbz-L-Glu(Otbu)
Boc-D-Glu-OH	Cbz-L-Glu(Ome)
Boc-Glu(obzl)-NH2	Cbz-D-Glu(OtBu)-OH
Boc-Glu（trt）-OH	Cbz-L-Glu(Ome)-OtBu
Boc-L-Glu(OcHx)-OH	Cbz-L-Glu-OBzl.DCHA
Boc-L-Glu(OtBu)-OH	Cbz-L-Glu(Oet)-OH
Boc-Glu(Osu)-Otbu	Boc-Glu-Otbu（Osu）

Te mana rangatira

1. Kei te waatea te ratonga R&D
2. Ko te kaihanga tiwhikete ISO, te kounga o te kounga
3.He akoranga katoa o te mahi whai muri i te wa e whakaputa ana
4.High utu whai hua
5.Ko nga tuhinga tiwhikete kounga e whakaratohia ana mo te tono a te kaihoko
6.Ratonga nui i muri i te hoko, te pupuri hononga tata ki te kaihoko
7.Full rauemi hei awhina i te whakaheke i nga utu kaipuke
Ko te tauira 8.Free ka tukuna ki te tirotiro i te kounga i mua i tetahi utu
9. I whiriwhiria te wa utu
10.Assit kiritaki e mahi ana ki nga take i Haina