Haina 200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH Kaihanga me te wheketere |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH

Whakaahuatanga Poto:

Te ahua	Maama ki te Kiriata-White ranei te paura tioata.
MF	C24H38N4O7S
MW	526.65
Maamaa	98+

Tukuna he imeera ki a matou

Taipitopito Hua

Te tikanga kawe me te tikanga tuku e taunaki ana:
ma te hau, ma te moana, ma te tere ranei

Tikanga rokiroki:
Kua hiri ki te maroke, Rokiroki ki roto i te pouaka tio, i raro i te -20°C

Te Rahi Ota Mokito:
Te whiriwhiringa

Tiwhikete:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e waatea ana

Nga kupu taurite

N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl)sulfonyl]amino]iminomethyl]-N2-BOC-L-ornithine;
Nα-Boc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl)-L-arginine;
Nalpha-Boc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-sulfonyl)-L-arginine;
BOC-ARGININE(PBF)-OH;BOC-L-ARG(PBF)-OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

Te takai o roto

I te nuinga o te wa ka whakamahia ki te kohi paura.A ka taea e ratou te aukati i te ra me te wai kia kino.

tarapi waho

Ka taea e te kaata pakeke te tiaki i o hua mai i te pakaru me te makuku.

Nga tono

Ko Boc-Arg (Pbf) -OH he pärönaki arginine.
Ko te Bivalirudine, he anticoagulant waihanga he whanaunga 20-peptide o te hirudin, i whakaaetia mo te hoko i te United States i te tau 2000. Ko te werohanga he mea ma, he maatete, he totoka amorphous ranei.Ka taea e te Bivarudine te herea motuhake ki te waahi o te thrombin catalytic me te waahi herea o waho o te anion, me te aukati tika i te mahi o te thrombin, na reira ka aukati i te tauhohenga i whakahiatohia me te whakaawehia e te thrombin, a ka taea te whakahoki mai.Ko te Bivarudine te nuinga o te whakamahi hei anticoagulant mo te wawaotanga mate coronary percutaneous elective (PCI) i roto i nga pakeke.
Ko te Bivarudine te aukati tika o te thrombin, e herea ana ki nga waahi catalytic me nga waahi here-anion o te thrombin kore me te thrombus.Ko te tukanga here i waenga i te bivaludine me te thrombin ka taea te whakahoki, a ka taea e te thrombin te whakahoki mai i te mahi koiora taketake o te thrombin ma te enzymolysis ata o te here peptide i waenga i te bivaludine Arg3-Pro4.
I roto i nga rangahau in vitro kua whakaatuhia ko te bivarudine kaore e taea te aukati i te thrombin kore noa o te taha, engari ka aukati ano hoki i te thrombin e herea ana me nga toto toto me te kore e whakakorehia e nga matū i tukuna e nga platelets.Ka taea e ia te whakaroa i te wa prothrombin partial (APTT), te wa thrombin (TT), te wa prothrombin (PT) me te wa coagulation kaha (ACT) ka whakahohehia e te plasma noa.He hononga ahorangi me te kukū o te bivarudine, engari mena kei te noho tenei hononga i roto i te tono haumanu kaore i te maarama.
Kua korerohia i roto i nga tuhinga ko nga rongoa o nga turoro e pa ana ki te angioplasty coronary percutaneous (PTCA) he raupapa i muri i te whakahaerenga o te bivarudine.I whakawhiwhia te manawanui ki te 1 mg / kg i roto i te toto hei horopeta kawenga, ka whai i tetahi atu whaowhia IV o 2.5 mg / kg / hr mo nga haora 4, i pumau ki te 12.3 ± 1.7 mg / ml i roto i te vivo.Ka whakakorehia te Bivarudine mai i te plasma na roto i te whakamaaramatanga o te renal hydrolysis me te paheketanga o te protease.Ko te haurua o te ora o nga turoro me nga mahi renal noa he 25 meneti, a ka roa ake te haurua o te oranga o nga turoro me te ngoikore o te renal.Tata ki te 25% o te bivarudine ka taea te tango ma te whakaheke toto me te whakakore ma te hemodialysis.Me aro turukihia te ACT mo nga turoro he mate whatukuhu.I roto i nga kaiwhaiwhai hauora, ka kitea tonu te paanga anticoagulant i muri i te whakahaerenga o te bivarudine, me te roa o te PT, ACT me te APTT.Kotahi ki te rua haora i muri i te tangohanga, ka hoki a ACT ki te taumata o mua i te whakahaerenga.

hua e pa ana

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg(Cbz)-OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg(NO2)-OH
L-Arg(Pbf)-OH	Fmoc-L-Arg(Pbf)-OH
D-Arg(NO2)-OH / N-NO2-D-Arg	Fmoc-HoArg(Pbf)-OH
HL-Arg(NO2)-OH	Fmoc-Arg(Tos)-OH
HL-Arg(Tos)-OH	Fmoc-D-Arg(Tos)-OH
L-Arg-NH2	Fmoc-D-Arg(Pbf)-OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg(Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg(Pbf)-OH
Boc-L-Arg-Ome	Cbz-D-Arg(pbf).CHA
Boc-L-Arg(Tos)-OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg(NO2)-OH	L-Arg(Pbf)-Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Te mana rangatira

1. Kei te waatea te ratonga R&D
2. Ko te kaihanga tiwhikete ISO, te kounga o te kounga
3.He akoranga katoa o te mahi whai muri i te wa e whakaputa ana
4.High utu whai hua
5.Ko nga tuhinga tiwhikete kounga e whakaratohia ana mo te tono a te kaihoko
6.Ratonga nui i muri i te hoko, te pupuri hononga tata ki te kaihoko
7.Full rauemi hei awhina i te whakaheke i nga utu kaipuke
Ko te tauira 8.Free ka tukuna ki te tirotiro i te kounga i mua i tetahi utu
9. I whiriwhiria te wa utu
10.Assit kiritaki e mahi ana ki nga take i Haina