Haina 15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH Kaihanga me te wheketere |Jiayinglai

15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Whakaahuatanga Poto:

Te ahua	Maama ki te Kiriata-White ranei te paura tioata.
MF	C16H23NO5
MW	309.36
Maamaa	98+

Tukuna he imeera ki a matou

Taipitopito Hua

Te tikanga kawe me te tikanga tuku e taunaki ana:
ma te hau, ma te moana, ma te tere ranei

Tikanga rokiroki:
Puritia ki te wahi pouri, Hiri ki te maroke, Te Pawera Rua

Te Rahi Ota Mokito:
Te whiriwhiringa

Tiwhikete:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e waatea ana

Nga kupu taurite

Boc-O-Benzyl-L-threonine;
BOC-THR-OH;
BOC-THR(BZL)-OH;
Butoxacarbonylbenzylthreonine;
NT-boc-O-benzyl-L-threonine*tiohio;
O-benzyl-N-tert-butoxycarbonyl-L-threonine;
N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE;
NALPHA-tert-Butoxycarbonyl-O-benzyl-L-threonine

Te takai o roto

I te nuinga o te wa ka whakamahia ki te kohi paura.A ka taea e ratou te aukati i te ra me te wai kia kino.

tarapi waho

Ka taea e te kaata pakeke te tiaki i o hua mai i te pakaru me te makuku.

Nga tono

Te paura tioata ma;Karekau e rewa ki te wai me te hinu etera, ka whakarewahia ki te ethyl acetate me te methanol;mp he 115-116 ℃;Te hurihanga motuhake [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
Ka whakamahia mo te whakahiato polypeptide, hei monomer tiaki waikawa amino.
I whakatarewahia te O-benzyl-l-threonine i roto i te wairewa dioxane me te acylated ki te tert-butylcarbonyl azide kia puta mai he hua masivesivá, i tangohia e te ethyl acetate i te pH o 9-10 katahi ka rerystallized.
He wahanga kaha o te thymic oietin Ⅱ o nga mea huna o thymus.Ko Thymoietin II he puhui polypeptide kotahi kua wehea mai i te homoni thymus.E 49 nga waikawa amino kei roto, a ko te wahanga mekameka peptide e 5 nga waikawa amino he rite katoa nga mahi tinana ki te thymoietin II.No reira, ka kiia tenei wahanga pentapeptide ko te thymus pentapeptide.He papatipu wetekina, he paura ranei.
Ko tetahi o nga mahi a te thymus pentapeptide ko te whakaawe i te rereketanga o nga pūtau T.Ka taea e ia te whakakorikori i te hurihanga o Thy-1- prothorax cells ki Thy-1+ T cells.Ko te rereketanga o nga pūtau T ka takawaenga e te pikinga o nga taumata cAMP intracellular.Ko tetahi atu mahi taketake o te thymus pentapeptides ko te here ki nga kaiwhakawhiwhi motuhake o nga pūtau T toto peripheral pakeke, te whakanui ake i te taumata o te cAMP intracellular, na reira ka whakaawe i te raupapa o nga tauhohenga intracellular, koinei hoki te putake o tana mahi immunomodulatory.I roto i te ahua o te tinana, i whakaatu te thymus pentapeptide i te kaha whakaihiihi i te aukati, ka tino whakanui ake i te tere o te hanganga E rosette me te tere hurihanga o nga lymphocytes splenic, te whakarei ake i nga waahanga rereke o te urupare aukati tuatahi, tuarua ranei, me te whakanui ake i te maha o te momo IgM me te IgG ranei IgA momo antibody hanga pūtau.Ka taea hoki e Thymus pentapeptide te whakarei ake i te mahi phagocytosis o te macrophages, te whakanui ake i te mahi a te enzyme me te phagocytosis o te polymorphonuclear neutrophils, te whakanui ake i te ihirangi antibody tohanga, me te whakarei ake i te mahi aukati o nga toto toto whero.Ka taea e Thymus pentapeptide te whakahohe i nga pūtau pai CD4 me te CD8, kia roa ake ai te ora o nga pūtau Tc motuhake, engari ka taea hoki te whakahohe i nga pūtau Th me te whakaawe i te mahi o nga pūtau Ts.Ko nga hua antiinfectious me te rongoa o te thymus pentapeptide e pa ana ki tana whakarei ake i nga mahi a te TC.Ko te nui o te thymus pentapeptide ka taea te whakanui ake i te hanga o te interferon i roto i te aukati mate-mate.Te whakakorikori me te whakatairanga i te rereketanga me te pakeketanga o nga pūtau T;Ko te CD4/CD8 he mea noa ma te whakarite i te owehenga o nga wahanga T lymphocyte;Whakanuia te mahi phagocytosis o macrophages;Whakarei ake i te mahi aukati toto toto whero;Whakanuia te mahi o nga pūtau whakamate maori;Whakanuia te taumata o te whakangao interleukin-2 me te whakapuakitanga o te kaiwhakawhiwhi;Whakanuia te hanga o te γ interferon i roto i nga pūtau mononuclear toto peripheral;Whakanuia te mahi SOD i roto i te serum.
Ka taea te whakamahi i roto i nga turoro puku kino me te ngoikore o te mahi aukati i muri i te radiotherapy me te chemotherapy.Te maimoatanga o te mate pukupuku B;Nga mahi pokanga nui me nga mate kino;Nga mate autoimmune penei i te rheumatoid arthritis, lupus erythematosus;Momo II mate huka mellitus, mate menopause;He tangata kua ngoikore te mahi aukati.

hua e pa ana

Fmoc-L-Thr(tBu)-Phe-OH	Boc-D-Thr-OH
HL-Thr-OH	Boc-D-Thr(me)-OH
DL-Thr	Boc-D-Thr(Bzl)-OH
HL-allo-Thr-OH	Cbz-Thr-OH
L-Thr(bzl)	Cbz-Thr-Obzl
HL-Thr(tBu)-OH	ZL-Thr-ome
L-Thr(me)	Cbz-D-Thr-OH
Thr-Otbu.hcl	Cbz-L-Thr(tBu)-OH
L-Thr(bzl).HCl	Cbz-L-Thr(bzl)-OH
L-Thr(me).Hcl	Cbz-L-Thr(tBu)-OH DCHA
L-Thr-Obzl.HCl	Fmoc-L-Thr-OH
HL-Thr-OMe.HCl	fmoc-L-Thr-OtBu
L-Thr-Oet.Hcl	Fmoc-L-Thr-Obzl
L-Allo-Thr-Ome.Hcl	Fmoc-L-Allo-Thr-OH
HL-Thr-OBzl·oxalate	Fmoc-Thr(tBu)-OH
D-Thr(bzl).HCl	Fmoc-L-Thr(bzl)-OH
D-Thr-Oet.Hcl	Fmoc-D-Thr-OH
D-Thr-Obzl.HCl	Fmoc-D-Thr(bzl)-OH
D-Thr-Ome.HCl	Fmoc-D-Thr(tBu)-OH
DL-Thr-Ome.HCl	Fmoc-L-Thr(tBu)-Ser-OH
Boc-L-Thr-OtBu	Boc-n-me-l-thr(bzl).CHA
Boc-L-Thr-OH	Fmoc-N-Me-L-Thr(bzl)-OH
Boc-L-allo-Thr-OH	Fmoc-L-Thr(tBu)-Gly-OH
Boc-Thr-OMe	(2S,3S)-2-Amino-3-methoxybutanoic acid/L-AlloThr(Me)
Boc-Thr-Obzl	(2S,3S)-2-Amino-3-methoxybutanoic acid/BOC-AlloThr(Me)
Boc-L-Thr(tBu)-OH	HL-Thr(Bzl)-OBzl.oxalate
Boc-L-Thr(Bzl)-OH	Boc-D-Thr-Ome
Boc-L-Thr(me)-OH

Te mana rangatira

1. Kei te waatea te ratonga R&D
2. Ko te kaihanga tiwhikete ISO, te kounga o te kounga
3.He akoranga katoa o te mahi whai muri i te wa e whakaputa ana
4.High utu whai hua
5.Ko nga tuhinga tiwhikete kounga e whakaratohia ana mo te tono a te kaihoko
6.Ratonga nui i muri i te hoko, te pupuri hononga tata ki te kaihoko
7.Full rauemi hei awhina i te whakaheke i nga utu kaipuke
Ko te tauira 8.Free ka tukuna ki te tirotiro i te kounga i mua i tetahi utu
9. I whiriwhiria te wa utu
10.Assit kiritaki e mahi ana ki nga take i Haina