Haina 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Kaihanga me te wheketere |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Whakaahuatanga Poto:

Te ahua	Maama ki te Kiriata-White ranei te paura tioata.
MF	C16H22N2O6
MW	338.36
Maamaa	98+

Tukuna he imeera ki a matou

Taipitopito Hua

Te tikanga kawe me te tikanga tuku e taunaki ana:
ma te hau, ma te moana, ma te tere ranei

Tikanga rokiroki:
I hiri ki te maroke, Te Pawera o te rūma

Te Rahi Ota Mokito:
Te whiriwhiringa

Tiwhikete:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC e waatea ana

Nga kupu taurite

(S)-ethyl 2-(tert-butoxycarbonylaMino)-3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, ethyl ester

Te takai o roto

I te nuinga o te wa ka whakamahia ki te kohi paura.A ka taea e ratou te aukati i te ra me te wai kia kino.

tarapi waho

Ka taea e te kaata pakeke te tiaki i o hua mai i te pakaru me te makuku.

Nga tono

Nidanib, he matū.Ingoa matū 1 h - indole - 6 - waikawa carboxylic, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland of methyl] - 2 - hāora -, methyl ester, (z) - Ma te haumanu, ka whakamahia tenei hua ki te rongoa i te fibrosis pulmonary idiopathic (IPF).
Kua ako a Nidanib i nga turoro 1,529 me te fibrosis pulmonary idiopathic (IPF) i roto i nga whakamatautau haumanu maha.Ko nga raraunga haumaru e whakaatuhia ana i runga i te whakataurite o nga turoro 1061 i whakawhiwhia ki te nidanib 150 mg e rua nga wa i ia ra me te placebo i roto i nga waahanga 52-wiki 3, te matapōkeretanga, te rua-matapo, nga rangahau placebo-whakahaere (INPULSIS-1 me INPULSIS-2).Ko nga kino kino e pa ana ki te whakamahinga o te nidanib ko te mate pukupuku, te nausea me te ruaki, te mamae o te puku, te mate o te hiahia, te mate taimaha, me te piki ake o nga enzyme ate.Tena koa tirohia te [Whakatupatotanga] mo te whakahaere i nga tauhohenga kino.Ko te Whakar
Ko Nidanib he taputapu mo te P-gp (tirohia te Pharmacokinetics).I roto i te rangahau motuhake mo nga taunekeneke tarukino, ko te whakahaere whakakotahi o te ketoconazole, he aukati P-gp kaha, ka piki ake te rongo ki te nidanib ki te 1.61 nga wa i te waahi i raro i te pihi (AUC) me te 1.83 nga wa ma te tihi teitei (Cmax).
I roto i te rangahau taunekeneke tarukino me te kaha P-gp inducer rifampicin, ka heke te rongo ki te nidanib ki te 50.3%, ka inehia e te waahi i raro i te pihi (AUC), ka honoa ki te rifampicin ki te Nidanib anake.Ma te kukū teitei (Cmax), ka heke ki te 60.3%.
I te wa e tukuna ana me tenei hua, ka taea e nga aukati P-gp kaha (hei tauira, te ketoconazole, erythromycin ranei) te whakanui ake i te rongo ki te nidanib.I enei keehi, me ata tirotiro te manawanui o te manawanui ki te nidanib.Ko te whakahaere i nga tauhohenga kino ka hiahia kia whakamutua, whakaheke i te horopeta, ka mutu ranei te maimoatanga me tenei hua (tirohia te [Whakamahinga me te horopeta]).
Ka taea e nga kaiwhakangungu kaha P-gp (hei tauira, rifampicin, carbamazepine, phenytoin me St. John's wort) te whakaiti i te rongo ki te nidanib.Ko nga huinga rereke me te kore, iti ranei te whakauru P-gp me whakaaro.

hua e pa ana

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Cchloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe（4-NO2）-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe（4-NO2）.H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Te mana rangatira

1. Kei te waatea te ratonga R&D
2. Ko te kaihanga tiwhikete ISO, te kounga o te kounga
3.He akoranga katoa o te mahi whai muri i te wa e whakaputa ana
4.High utu whai hua
5.Ko nga tuhinga tiwhikete kounga e whakaratohia ana mo te tono a te kaihoko
6.Ratonga nui i muri i te hoko, te pupuri hononga tata ki te kaihoko
7.Full rauemi hei awhina i te whakaheke i nga utu kaipuke
Ko te tauira 8.Free ka tukuna ki te tirotiro i te kounga i mua i tetahi utu
9. I whiriwhiria te wa utu
10.Assit kiritaki e mahi ana ki nga take i Haina